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GPCR assays
Scottish Biomedical offers a range of flexible cell-free and cell-based assays designed to study binding and functional properties of agonists and antagonists against a wide range of GPCR targets.
Our experienced scientists are proficient in GPCR cell line development, membrane preparation, radioligand binding assays and whole cell signaling assays. Each assay is designed with the functional properties of your specific GPCR in mind.
- Wide range of off-the-shelf or custom developed GPCR targets
- HTS, selectivity profiling, dose response curves
- Radioligand binding
- GTP(γ)S assay
- Second messenger accumulation (calcium / cyclic nucleotide)
- Kinase activation
- Arrestin receptor interaction
- Signaling pathway dissection
- In vivo pharmacology (inflammation, metabolism, CNS disorders & pain)
Current targets include:
Adenosine: A1, A2A, A2B, A3
Adrenergic: a1A, a1B, a2A, a2B, a2C, b1, b2, b3
Angiotensin: AT1, AT2
Apelin: APJ
Bombesin: BB1, BB2, BB3
Bradykinin: B1, B2
Calcitonin Gene Related Peptide: CGRP1
Cannabinoid: CB1, CB2
Chemokine: CCR1, CCR2B, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CXCR1, CXCR2, CXCR3, CXCR4, CXCR6, CXCR7
Dopamine: D1, D2, D3, D4, D5
Endothelin: ETA, ETB
GABA: B1a, B1b
Galanin: Gal1, Gal2
Glucagon: GLP1
Histamine: H1, H2, H3, H4
Kappa Opioid
Leukotriene: BLT1, CysLT1
Lysophospholipid: S1P2, S1P3
Melanin: MCH1, MCH2
Melanocortin: MC1, MC3, MC4, MC5
Melatonin: MT1, MT2
Muscarinic: M1, M2, M3, M4
Mu Opioid
Neurokinin: NK1
Other targets available on request.
Contact us to discuss how our GPCR assays can advance your drug discovery project.